Recent advances in high-resolution sequencing have led to the discovery of unique peptides derived from mitochondrial genome.1-2Currently 8 peptides are identified: humanin, mitochondrial open reading frame of the 12S tRNA-c (MOTS-c), and six small humanin-like peptides (SHLP1-6). 1-2All of these peptides are released into cytosol from mitochondria. SHLP6 has been shown to increase apoptosis with potential cancer targeting roles and also may be involved in aging.1-2