Agmatine, an aminoguanidine ((4-aminobutyl)guanidine), was discovered in 1910 by the Nobel laureate Albrecht Kossel.It is a common natural compound synthesized by decarboxylation of the amino acid arginine, hence also known as decarboxylated arginine.
Agmatine has been shown to exert modulatory action at multiple molecular targets, notably: neurotransmitter systems, key ion channels, nitric oxide (NO) synthesis and polyamine metabolism, thus providing bases for further research into potential applications.