Wnt/β-catenin agonist 3 hydrochloride is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 (compound 98) can be used for the research of osteoporosis.In Vitro: Wnt/β-catenin agonist 3 hydrochloride (compound 98; 24 h; HEK293 and SW480 cells) has 54% cell activity at 120 μM concentration compared with the positive control group LiCl (20mM).
Wnt/β-catenin agonist 3 hydrochloride (30 and 60 μM; 24 h; HEK293 cells) is an activator for β-Catenin and deposits β-catenin.
Wnt/β-catenin agonist 3 hydrochloride (11 μM; 4 d) induces differentiation of ST2 cell line into osteoblasts and calcium deposition.