(S,R,S)-AHPC-Me (dihydrochloride)| ChemScene
(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].
| Trivial name | (S,R,S)-AHPC-Me (dihydrochloride) |
| Catalog Number | CS-0069711 |
| Alternative Name(s) | VHL ligand 2 (dihydrochloride); E3 ligase Ligand 1 (dihydrochloride) |
| Molecular Formula | 517.51 |
| Purity | >98% |
| Condensed Formula | C23H34Cl2N4O3S |
| Size | 500mg |
| Supplier Page | www.chemscene.com/CS-0069711.html |