SPAA-52| ChemScene
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research.IC50 & Target:IC50: 4 nM (LMW-PTP)In Vivo:
| Compound | SPAA-52 | |
| dose route | 2 mg/kg IV | 10 mg/kg PO |
| AUC (0?8 h) (nM h) | 15,100 | 37,300 |
| C0 or Cmax (nM) | 13,400 | 9690 |
| C0 or Cmax unbound (nM) | 332 | 233 |
| Vdss (L/kg) | 0.42 | |
| CL (mL/min/kg) | 5.65 | |
| T1/2 (h) | 1.41 | 4.2 |
| F (%) | 34 |
| Compound | SPAA-52 | |
| dose route | 3 mg/kg PO | |
| AUC (0-12 h) (nM h) | 4660 | |
| Cmax (nM) | 877 | |
| Cmax unbound (nM) | 21 | |
| Vdss (L/kg) | 0.42 | |
| Tmax (h) | 2.0 | |
| T1/2 (h) | 2.4 |
| Trivial name | SPAA-52 |
| Catalog Number | CS-0617377 |
| Molecular Formula | 388.03 |
| Purity | >98% |
| Condensed Formula | C8H8Br2N2O4S |
| Size | 25mg |
| Supplier Page | www.chemscene.com/CS-0617377.html |