NLS-StAx-h TFA is a selective, cell permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. NLS-StAx-h TFA efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h TFA shows anti-proliferation of cancer cells[2].IC50 & Target:IC50: 1.4 μM (Wnt)In Vitro:NLS-StAx-h (10 μM; 72 h) inhibits proliferation of colorectal cancer cells.
NLS-StAx-h (5 and 10 μM; 24 h) inhibits migration of colorectal cancer cells.