Disulfiram
Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).
| Trivial name | NSC 190940, Tetraethylthiuram disulfide, TETD |
| Catalog Number | S1680 |
| Molecular Formula | C25H21N3O |
| CAS# | 97-77-8 |
| Inchi | InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29) |
| Inchi Key | KHZOJCQBHJUJFY-UHFFFAOYSA-N |
| SMILES | CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Disulfiram(Antabuse).html |
| Additional Information | https://file.selleck.cn/downloads/struct/Disulfiram-Antabuse-chemical-structure-S1680.gif |