XL147 analogue
XL147 analogue (SAR245408) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. XL147 analogue induces apoptosis. Phase 1/2.
| Trivial name | SAR245408 |
| Catalog Number | S1118 |
| Molecular Formula | C21H16N6O2S2 |
| CAS# | 956958-53-5 |
| Inchi | InChI=1S/C21H16N6O2S2/c1-13-6-9-15(10-7-13)31(28,29)27-21-20(23-16-4-2-3-5-17(16)24-21)22-14-8-11-18-19(12-14)26-30-25-18/h2-12H,1H3,(H,22,23)(H,24,27) |
| Inchi Key | MQMKRQLTIWPEDM-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4 |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/XL147.html |
| Additional Information | https://file.selleck.cn/downloads/struct/XL147-chemical-structure-S1118.gif |