Sonidegib
Sonidegib is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.
| Trivial name | NVP-LDE225, Erismodegib |
| Catalog Number | S2151 |
| Molecular Formula | C17H16N4O2S2 |
| CAS# | 956697-53-3 |
| Inchi | InChI=1S/C17H16N4O2S2/c1-20-13-7-14(25(2)23)24-16(13)12-8-19-21(17(22)15(12)20)9-10-4-3-5-11(18)6-10/h3-8H,9,18H2,1-2H3 |
| Inchi Key | ZWKJWVSEDISQIS-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C3=C1C(=O)N(N=C3)CC4=CC(=CC=C4)N)SC(=C2)S(=O)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/LDE225(NVP-LDE225).html |
| Additional Information | https://file.selleck.cn/downloads/struct/LDE225-NVP-LDE225-chemical-structure-S2151.gif |