Sonidegib
Sonidegib is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.
| Trivial name | NVP-LDE225, Erismodegib |
| Catalog Number | S2151 |
| Molecular Formula | C26H26F3N3O3 |
| CAS# | 956697-53-3 |
| Inchi | InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+ |
| Inchi Key | VZZJRYRQSPEMTK-CALCHBBNSA-N |
| SMILES | CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/LDE225(NVP-LDE225).html |
| Additional Information | https://file.selleck.cn/downloads/struct/LDE225-NVP-LDE225-chemical-structure-S2151.gif |