Sonidegib
Sonidegib is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.
| Trivial name | NVP-LDE225, Erismodegib |
| Catalog Number | S2151 |
| Molecular Formula | C19H18ClN5OS |
| CAS# | 956697-53-3 |
| Inchi | InChI=1S/C19H18ClN5OS/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)22-14(8-15(21)26)18-24-23-11(3)25(18)19/h4-7,14H,8H2,1-3H3,(H2,21,26)/t14-/m0/s1 |
| Inchi Key | QECMENZMDBOLDR-AWEZNQCLSA-N |
| SMILES | CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)N)C4=CC=C(C=C4)Cl)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/LDE225(NVP-LDE225).html |
| Additional Information | https://file.selleck.cn/downloads/struct/LDE225-NVP-LDE225-chemical-structure-S2151.gif |