PF-477736
PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.
| Trivial name | PF-736, PF-00477736 |
| Catalog Number | S2904 |
| Molecular Formula | C22H25N7O2 |
| CAS# | 952021-60-2 |
| Inchi | InChI=1S/C22H25N7O2/c1-29-11-13(9-25-29)20-16-10-24-28-21(30)15-7-14(8-17(27-20)18(15)16)26-22(31)19(23)12-5-3-2-4-6-12/h7-12,19,27H,2-6,23H2,1H3,(H,26,31)(H,28,30)/t19-/m1/s1 |
| Inchi Key | NDEXUOWTGYUVGA-LJQANCHMSA-N |
| SMILES | CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)C(C5CCCCC5)N)N2 |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/pf-477736.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pf-477736-chemical-structure-s2904.gif |