PF-477736
PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.
| Trivial name | PF-736, PF-00477736 |
| Catalog Number | S2904 |
| Molecular Formula | C21H21BrN4O5 |
| CAS# | 952021-60-2 |
| Inchi | InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26) |
| Inchi Key | NEXGBSJERNQRSV-UHFFFAOYSA-N |
| SMILES | CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(C(=C3)OC)OC)OC |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/pf-477736.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pf-477736-chemical-structure-s2904.gif |