Quizartinib (AC220)
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.
| Trivial name | N/A |
| Catalog Number | S1526 |
| Molecular Formula | C33H41ClN8O2 |
| CAS# | 950769-58-1 |
| SMILES | CCC(=O)NC1CCC(CC1)N2C3=NC(=NC=C3CN(C2=O)C4=CC=CC=C4Cl)NC5=CC(=C(C=C5)N6CCN(CC6)C)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/AC-220.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AC220-chemical-structure-S1526.gif |