PCI-34051
PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. PCI-34051 induces caspase-dependent apoptosis.
| Trivial name | N/A |
| Catalog Number | S2012 |
| Molecular Formula | C17H16N2O3 |
| CAS# | 950762-95-5 |
| Inchi | InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20) |
| Inchi Key | AJRGHIGYPXNABY-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/pci-34051.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PCI-34051-chemical-structure-s2012.gif |