PCI-34051
PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. PCI-34051 induces caspase-dependent apoptosis.
| Trivial name | N/A |
| Catalog Number | S2012 |
| Molecular Formula | C22 H26 F N3 O2 |
| CAS# | 950762-95-5 |
| Inchi | InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28) |
| Inchi Key | KKYABQBFGDZVNQ-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=NC=C(C=C3)C(=O)NCC(C)(C)C |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/pci-34051.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PCI-34051-chemical-structure-s2012.gif |