Remodelin
Remodelin is a potential inhibitor of the acetyltransferase NAT10. It enhances nuclear shape and cellular fitness in both progeric cells and cells depleted of Lamin A/C by inhibiting NAT10. Remodelin exhibits anti-proliferation activity and significantly inhibits tumour growth and tumour cell proliferation in the PDX model of HNSCC.
| Catalog Number | E5782 |
| Molecular Formula | C20H17ClF4N4O4S |
| CAS# | 949912-58-7 |
| Inchi | InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1 |
| Inchi Key | XEAOPVUAMONVLA-QGZVFWFLSA-N |
| SMILES | C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/remodelin-e5782.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5782-Remodelin-chemical-structure.png |