Remodelin
Remodelin is a potential inhibitor of the acetyltransferase NAT10. It enhances nuclear shape and cellular fitness in both progeric cells and cells depleted of Lamin A/C by inhibiting NAT10. Remodelin exhibits anti-proliferation activity and significantly inhibits tumour growth and tumour cell proliferation in the PDX model of HNSCC.
| Catalog Number | E5782 |
| Molecular Formula | C22H18Cl2N8 |
| CAS# | 949912-58-7 |
| Inchi | InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32) |
| Inchi Key | AQGNHMOJWBZFQQ-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/remodelin-e5782.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5782-Remodelin-chemical-structure.png |