RN-1734
RN-1734 (TRPV4 Antagonist I) is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist with IC50 of 2.3 μM, 5.9 μM and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1734 alleviates demyelination and inhibits glial activation and the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.
| Trivial name | TRPV4 Antagonist I |
| Catalog Number | S2650 |
| Molecular Formula | C14H22Cl2N2O2S |
| CAS# | 946387-07-1 |
| Inchi | InChI=1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3 |
| Inchi Key | IHYZMEAZAIFMTN-UHFFFAOYSA-N |
| SMILES | CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/rn-1734.html |
| Additional Information | https://file.selleck.cn/downloads/struct/rn-1734-chemical-structure-s2650.gif |