Avutometinib
Avutometinib(RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.
| Trivial name | RO5126766,CH5126766,VS 6766, CKI-27, R-7304, RG-7304 |
| Catalog Number | S7170 |
| Molecular Formula | C₂₁H₁₈FN₅O₅S |
| CAS# | 946128-88-7 |
| Inchi | InChI=1S/C21H18FN5O5S/c1-12-15-5-4-14(31-21-25-7-3-8-26-21)11-17(15)32-20(28)16(12)10-13-6-9-24-19(18(13)22)27-33(29,30)23-2/h3-9,11,23H,10H2,1-2H3,(H,24,27) |
| Inchi Key | LMMJFBMMJUMSJS-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/ro5126766-ch5126766.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ch5126766-ro5126766-chemical-structure-s7170.gif |