Buparlisib (BKM120)

Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.

Price Not Available 10mM/1mL Buparlisib (BKM120) Supplier Page

Trivial name	NVP-BKM120
Catalog Number	S2247
Molecular Formula	C21 H23 F N2 O4
CAS#	944396-07-0
Inchi	InChI=1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)/t15?,18-/m0/s1
Inchi Key	ASXVEBPEZMSPHB-PKHIMPSTSA-N
SMILES	CC(C(=O)CF)NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/BKM-120.html
Additional Information	https://file.selleck.cn/downloads/struct/s2247-buparlisib-bkm120-chemical-structure.png