GSK1070916
GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.
| Trivial name | N/A |
| Catalog Number | S2740 |
| Molecular Formula | C27H25F3N8O2 |
| CAS# | 942918-07-2 |
| Inchi | InChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34) |
| Inchi Key | NBZFRTJWEIHFPF-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CC(=NN5C)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/gsk1070916.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK1070916-chemical-structure-s2740.gif |