GSK1070916
GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.
| Trivial name | N/A |
| Catalog Number | S2740 |
| Molecular Formula | C30H33N7O |
| CAS# | 942918-07-2 |
| Inchi | InChI=1S/C30H33N7O/c1-6-37-19-26(28(34-37)21-10-12-23(13-11-21)32-30(38)36(4)5)24-14-15-31-29-25(24)17-27(33-29)22-9-7-8-20(16-22)18-35(2)3/h7-17,19H,6,18H2,1-5H3,(H,31,33)(H,32,38) |
| Inchi Key | QTBWCSQGBMPECM-UHFFFAOYSA-N |
| SMILES | CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC=CC(=C5)CN(C)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/gsk1070916.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK1070916-chemical-structure-s2740.gif |