PF-562271 Besylate

PF-562271 Besylate is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.

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Trivial name	PF-00562271 Besylate
Catalog Number	S2672
Molecular Formula	C21H20F3N7O3S.C6H6O3S
CAS#	939791-38-5
Inchi	InChI=1S/C21H20F3N7O3S.C6H6O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16;7-10(8,9)6-4-2-1-3-5-6/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26 ,27,28,30);1-5H,(H,7,8,9)
Inchi Key	LKLWTLXTOVZFAE-UHFFFAOYSA-N
SMILES	CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C.C1=CC=C(C=C1)S(=O)(=O)O
Size	5mg
Supplier Page	http://www.selleckchem.com/products/pf-00562271.html
Additional Information	https://file.selleck.cn/downloads/struct/PF-00562271-chemical-structure-s2672.gif