Tucatinib
Tucatinib (Irbinitinib, ONT-380, ARRY-380) is an oral, potent, selective, reversible and ATP-competitive small-molecule inhibitor of ErbB-2 (also called HER2) with IC50s of 8 nM and 7 nM for ErbB-2 and p95 HER2, respectively in cell-based assays, showing ~500-fold selective for HER2 vs EGFR. It has potential antineoplastic activity.
| Trivial name | Irbinitinib, ONT-380, ARRY-380 |
| Catalog Number | S8362 |
| Molecular Formula | C26H24N8O2 |
| CAS# | 937263-43-9 |
| Inchi | InChI=1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31) |
| Inchi Key | SDEAXTCZPQIFQM-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/arry-380-ont-380.html |
| Additional Information | https://file.selleck.cn/downloads/struct/arry-380-ont-380-chemical-structure-s8362.gif |