OSI-027
OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.
| Trivial name | ASP4786, CERC 006, AEVI-006 |
| Catalog Number | S2624 |
| Molecular Formula | C26H24F3N7O3S |
| CAS# | 936890-98-1 |
| Inchi | InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36 ,38) |
| Inchi Key | PRAAPINBUWJLGA-UHFFFAOYSA-N |
| SMILES | C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/OSI027.html |
| Additional Information | https://file.selleck.cn/downloads/struct/OSI-027-chemical-structure-S2624.gif |