OSI-027
OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.
| Trivial name | ASP4786, CERC 006, AEVI-006 |
| Catalog Number | S2624 |
| Molecular Formula | C21H22N6O3 |
| CAS# | 936890-98-1 |
| Inchi | InChI=1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4,9-12,25H,5-8H2,1H3,(H,28,29)(H2,22,23,24)/t11-,12- |
| Inchi Key | JROFGZPOBKIAEW-HAQNSBGRSA-N |
| SMILES | COC1=CC=CC2=C1NC(=C2)C3=C4C(=NC=NN4C(=N3)C5CCC(CC5)C(=O)O)N |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/OSI027.html |
| Additional Information | https://file.selleck.cn/downloads/struct/OSI-027-chemical-structure-S2624.gif |