Ibrutinib
Ibrutinib is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.
| Trivial name | PCI-32765 |
| Catalog Number | S2680 |
| Molecular Formula | C21H19F4N7 |
| CAS# | 936563-96-1 |
| Inchi | InChI=1S/C21H19F4N7/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30) |
| Inchi Key | FYXRSVDHGLUMHB-UHFFFAOYSA-N |
| SMILES | CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/pci-32765.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PCI-32765-chemical-structure-s2680.gif |