Ibrutinib
Ibrutinib is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.
| Trivial name | PCI-32765 |
| Catalog Number | S2680 |
| Molecular Formula | C25H24N6O2 |
| CAS# | 936563-96-1 |
| Inchi | InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28) |
| Inchi Key | XYFPWWZEPKGCCK-UHFFFAOYSA-N |
| SMILES | C=CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/pci-32765.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PCI-32765-chemical-structure-s2680.gif |