Fedratinib (TG101348)
Fedratinib (SAR302503, TG101348) is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Fedratinib also inhibits FMS-like tyrosine kinase 3 (FLT3) and RET (c-RET) with IC50 of 15 nM and 48 nM, respectively. Fedratinib has potential antineoplastic activity. Fedratinib inhibits proliferation and induces apoptosis. Phase 2.
| Trivial name | SAR302503 |
| Catalog Number | S2736 |
| Molecular Formula | C27H36N6O3S |
| CAS# | 936091-26-8 |
| Inchi | InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) |
| Inchi Key | JOOXLOJCABQBSG-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Fedratinib-SAR302503-TG101348.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TG-101348-chemical-structure-s2736.gif |