TG101209
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.
| Trivial name | N/A |
| Catalog Number | S2692 |
| Molecular Formula | C26H35N7O2S |
| CAS# | 936091-14-4 |
| Inchi | InChI=1S/C26H35N7O2S/c1-19-18-27-25(29-20-9-11-22(12-10-20)33-15-13-32(5)14-16-33)30-24(19)28-21-7-6-8-23(17-21)36(34,35)31-26(2,3)4/h6-12,17-18,31H,13-16H2,1-5H3,(H2,27,28,29,30) |
| Inchi Key | JVDOKQYTTYUYDV-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)N4CCN(CC4)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/tg101209.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TG101209-chemical-structure-s2692.gif |