Oprozomib
Oprozomib is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.
| Trivial name | ONX 0912, PR-047 |
| Catalog Number | S7049 |
| Molecular Formula | C25H32N4O7S |
| CAS# | 935888-69-0 |
| Inchi | InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18 -,19-,25?/m0/s1 |
| Inchi Key | SWZXEVABPLUDIO-QNLBTCDKSA-N |
| SMILES | CC1=NC=C(S1)C(=O)NC(COC)C(=O)NC(COC)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(CO3)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/oprozomib-onx-0912.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s7049-chemical-structure-oprozomib-onx-0912.gif |