Cobimetinib (GDC-0973)

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, and showing no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3.

Price Not Available 5mg Cobimetinib (GDC-0973) Supplier Page

Trivial name	RG7420,XL518
Catalog Number	S8041
Molecular Formula	C21H21F3IN3O2
CAS#	934660-93-2
Inchi	InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1
Inchi Key	BSMCAPRUBJMWDF-KRWDZBQOSA-N
SMILES	C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
Size	5mg
Supplier Page	http://www.selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html
Additional Information	https://file.selleck.cn/downloads/struct/gdc-0973-xl518-rg7420-chemical-structure-s8041.gif