ENMD-2076
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.
| Trivial name | N/A |
| Catalog Number | S1181 |
| Molecular Formula | C24H26N4O3S |
| CAS# | 934353-76-1 |
| Inchi | InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22/h1-5,8-12,18,26H,6-7,13-17H2 |
| Inchi Key | XAYGBKHKBBXDAK-UHFFFAOYSA-N |
| SMILES | C1CC1CN2CCN(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C4=CC=CC5=C4N=CC=C5 |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/enmd-2076.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ENMD-2076-chemical-structure-S1181.gif |