ENMD-2076
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest. Phase 2.
| Trivial name | N/A |
| Catalog Number | S1181 |
| Molecular Formula | C14H19Cl2N3O2S |
| CAS# | 934353-76-1 |
| Inchi | InChI=1S/C14H17N3O2S.2ClH/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14;;/h2-6,9,11,16H,7-8,10H2,1H3;2*1H |
| Inchi Key | YHYNDFTUZMEYNX-UHFFFAOYSA-N |
| SMILES | CC1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl.Cl |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/enmd-2076.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ENMD-2076-chemical-structure-S1181.gif |