2-Hydroxybenzylamine (2-(Aminomethyl)phenol, 2-HOBA, NSC 127870) is a naturally occurring compound found in buckwheat and is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. 2-HOBA reduces inflammation and plaque apoptotic cells and promotes efferocytosis and features of stable plaques. 2-HOBA has potential for use as a nutrition supplement due to its ability to protect against the damaging effects of oxidative stress.