R 59-022
R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.
| Trivial name | DKGI-I, Diacylglycerol kinase inhibitor I |
| Catalog Number | E7773 |
| Molecular Formula | C21H26O2 |
| CAS# | 93076-89-2 |
| Inchi | InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3/t17-,18-,19+,20+,21+/m1/s1 |
| Inchi Key | IMSSROKUHAOUJS-MJCUULBUSA-N |
| SMILES | CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/r-59-022.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7773-r-59-022-chemical-structure-tube.png |