GSK461364
GSK461364 (GSK461364A) inhibits purified Plk1 with Ki of 2.2 nM in a cell-free assay. It is more than 1000-fold selective against Plk2/3.
| Trivial name | GSK461364A |
| Catalog Number | S2193 |
| Molecular Formula | C27H28F3N5O2S |
| CAS# | 929095-18-1 |
| Inchi | InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 |
| Inchi Key | ZHJGWYRLJUCMRT-QGZVFWFLSA-N |
| SMILES | CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/GSK461364.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK-461364-chemical-structure-S2193.gif |