RAF265 (CHIR-265)
RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. RAF265 (CHIR-265) induces cell cycle arrest and apoptosis. Phase 2.
| Trivial name | N/A |
| Catalog Number | S2161 |
| Molecular Formula | C19H17NO3 |
| CAS# | 927880-90-8 |
| Inchi | InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23) |
| Inchi Key | VZQDDSYKVYARDW-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C(=O)NC1=CC2=C(C=C1)C3=CC=CC=C3C(=O)C2=O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/RAF265(CHIR-265).html |
| Additional Information | https://file.selleck.cn/downloads/struct/RAF265-CHIR-265-chemical-structure-S2161.gif |