RAF265 (CHIR-265)
RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. RAF265 (CHIR-265) induces cell cycle arrest and apoptosis. Phase 2.
| Trivial name | N/A |
| Catalog Number | S2161 |
| Molecular Formula | C24H16F6N6O |
| CAS# | 927880-90-8 |
| Inchi | InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) |
| Inchi Key | YABJJWZLRMPFSI-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/RAF265(CHIR-265).html |
| Additional Information | https://file.selleck.cn/downloads/struct/RAF265-CHIR-265-chemical-structure-S2161.gif |