RAF265 (CHIR-265)

RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. RAF265 (CHIR-265) induces cell cycle arrest and apoptosis. Phase 2.

Price Not Available 10mM/1mL RAF265 (CHIR-265) Supplier Page

Trivial name	N/A
Catalog Number	S2161
Molecular Formula	C26H25F2N3O6
CAS#	927880-90-8
Inchi	InChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)/t20-,23- /m0/s1
Inchi Key	OOBJCYKITXPCNS-REWPJTCUSA-N
SMILES	CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/RAF265(CHIR-265).html
Additional Information	https://file.selleck.cn/downloads/struct/RAF265-CHIR-265-chemical-structure-S2161.gif