Refametinib (RDEA119)
Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
| Trivial name | Bay 86-9766 |
| Catalog Number | S1089 |
| Molecular Formula | C19H20F3IN2O5S |
| CAS# | 923032-37-5 |
| Inchi | InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28,29)19(4-5-19)8-11(27)9-26/h2-3,6-7,11,24-27H,4-5,8-9H2,1H3/t11-/m0/s1 |
| Inchi Key | RDSACQWTXKSHJT-NSHDSACASA-N |
| SMILES | COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/refametinib-rdea119-bay86-9766.html |
| Additional Information | https://file.selleck.cn/downloads/struct/RDEA119-BAY-869766-chemical-structure-S1089.gif |