TM-1| ChemScene

TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation.IC50 & Target: IC50: 2.97 μM (PDK1), 5.2 μM (PDK2)In Vitro: TM-1 (0-10 μM) inhibits PDHK1 activity with the inhibition rate of 80.5% (dosage at 10 μM) and an IC50 value of 2.97 μM.
TM-1 (0-2.1 μM; 12 h) shows anti-osteosarcoma activity and inhibits MG-63 cells with an EC50 value of 14.5 μM.
TM-1 (3, 6, 12 μM; 24 h) decreases PDHC phosphorylation of both Ser293 and Ser232 sites in a dose-dependent manner.

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Trivial name TM-1
Catalog Number CS-0134248
Molecular Formula 468.54
CAS# 921099-13-0
Purity >98%
Condensed Formula C26H32N2O6
Size 1mg
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