Resmetirom (MGL-3196)
Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.
Trivial name | VIA-3196 |
Catalog Number | S6663 |
Molecular Formula | C17H12Cl2N6O4 |
CAS# | 920509-32-6 |
Inchi | InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28) |
Inchi Key | FDBYIYFVSAHJLY-UHFFFAOYSA-N |
SMILES | CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/mgl-3196.html |
Additional Information | https://file.selleck.cn/downloads/struct/mgl-3196-chemical-structure-s6663.gif |