Evofosfamide (TH-302)
Evofosfamide (TH-302) is a selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.
| Catalog Number | S2757 |
| Molecular Formula | C9H16Br2N5O4P |
| CAS# | 918633-87-1 |
| Inchi | InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19) |
| Inchi Key | UGJWRPJDTDGERK-UHFFFAOYSA-N |
| SMILES | CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/th-302.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TH-302-chemical-structure-s2757.gif |