PLX-4720
PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.
| Trivial name | N/A |
| Catalog Number | S1152 |
| Molecular Formula | C17H14ClF2N3O3S |
| CAS# | 918505-84-7 |
| Inchi | InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) |
| Inchi Key | YZDJQTHVDDOVHR-UHFFFAOYSA-N |
| SMILES | CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)Cl)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/PLX-4720.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PLX-4720-chemical-structure-S1152.gif |