Vemurafenib (PLX4032)
Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.
| Trivial name | RG7204, RO5185426,PLX4032 |
| Catalog Number | S1267 |
| Molecular Formula | C23H18ClF2N3O3S |
| CAS# | 918504-65-1 |
| Inchi | InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28) |
| Inchi Key | GPXBXXGIAQBQNI-UHFFFAOYSA-N |
| SMILES | CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/PLX-4032.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PLX-4032-RG7204-chemical-structure-S1267.gif |