Vemurafenib (PLX4032)

Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.

Price Not Available 10mM/1mL Vemurafenib (PLX4032) Supplier Page
Trivial name RG7204, RO5185426,PLX4032
Catalog Number S1267
Molecular Formula C23H18ClF2N3O3S
CAS# 918504-65-1
Inchi InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
Inchi Key GPXBXXGIAQBQNI-UHFFFAOYSA-N
SMILES CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F
Size 10mM/1mL
Supplier Page http://www.selleckchem.com/products/PLX-4032.html
Additional Information https://file.selleck.cn/downloads/struct/PLX-4032-RG7204-chemical-structure-S1267.gif