Vemurafenib (PLX4032)

Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.

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Trivial name	RG7204, RO5185426,PLX4032
Catalog Number	S1267
Molecular Formula	C21H22ClN3O
CAS#	918504-65-1
Inchi	InChI=1S/C21H22ClN3O/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2/t16-,19-,21-/m1/s1
Inchi Key	RLKRLNQEXBPQGQ-OZOXKJRCSA-N
SMILES	C1CC(CN(C1)C2CC3=CC=CC=C3C2OC4=C(C=C(C=C4)C#N)Cl)N
Size	10mg
Supplier Page	http://www.selleckchem.com/products/PLX-4032.html
Additional Information	https://file.selleck.cn/downloads/struct/PLX-4032-RG7204-chemical-structure-S1267.gif