MK-2461
MK-2461 is a potent, multi-targeted inhibitor for c-Met(WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2.
| Trivial name | N/A |
| Catalog Number | S2774 |
| Molecular Formula | C34H29N7O |
| CAS# | 917879-39-1 |
| Inchi | InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36) (H,39,42) |
| Inchi Key | BIWGYFZAEWGBAL-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=C(N=C6C=C7C(=NC=N7)C=C6N5)C8=CC=CC=C8 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/mk-2461.html |
| Additional Information | https://file.selleck.cn/downloads/struct/MK-2461-chemical-structure-s2774.gif |