APTO-253

APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).

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Trivial name	LOR-253, LT-253
Catalog Number	S6963
Molecular Formula	C22H14FN5
CAS#	916151-99-0
SMILES	CC1=C(C2=NC3=C([NH]2)C4=CC=CN=C4C5=C3C=CC=N5)C6=C([NH]1)C=CC(=C6)F
Size	5mg
Supplier Page	http://www.selleckchem.com/products/apto-253.html
Additional Information	https://file.selleck.cn/downloads/struct/s6963-apto-253-chemical-structure.gif