Cot inhibitor-2
Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM.
Catalog Number | E7678 |
Molecular Formula | C24H36O5 |
CAS# | 915363-56-3 |
Inchi | InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1 |
Inchi Key | PCZOHLXUXFIOCF-BXMDZJJMSA-N |
SMILES | CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/cot-inhibitor-2.html |
Additional Information | https://file.selleck.cn/downloads/struct/e7678-cot-inhibitor-2-chemical-structure-tube.png |