Veliparib (ABT-888)
Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3.
| Trivial name | NSC 737664 |
| Catalog Number | S1004 |
| Molecular Formula | C13H16N4O |
| CAS# | 912444-00-9 |
| Inchi | InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1 |
| Inchi Key | JNAHVYVRKWKWKQ-CYBMUJFWSA-N |
| SMILES | CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/ABT-888.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ABT-888-Veliparib-chemical-structure-S1004.gif |