Veliparib (ABT-888)
Veliparib (ABT-888, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Veliparib increases autophagy and apoptosis. Phase 3.
| Trivial name | NSC 737664 |
| Catalog Number | S1004 |
| Molecular Formula | C19H12F4N4O2 |
| CAS# | 912444-00-9 |
| Inchi | InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29) |
| Inchi Key | FYSRKRZDBHOFAY-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/ABT-888.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ABT-888-Veliparib-chemical-structure-S1004.gif |