Rabusertib (LY2603618)

Rabusertib (LY2603618, IC-83) is a highly selective Chk1 inhibitor with potential anti-tumor activity in a cell-free assay. IC50=7 nM, showing approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated. Rabusertib (LY2603618) induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Rabusertib (LY2603618) induces bak-dependent apoptosis in AML cell lines.

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Trivial name	IC-83
Catalog Number	S2626
Molecular Formula	C18H22BrN5O3
CAS#	911222-45-2
Inchi	InChI=1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25)/t13-/m0/s1
Inchi Key	SYYBDNPGDKKJDU-ZDUSSCGKSA-N
SMILES	CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OCC3CNCCO3
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/LY2603618-IC-83.html
Additional Information	https://file.selleck.cn/downloads/struct/LY2603618-chemical-structure-s2626.gif