BAY 60-6583 is a non-purine and selective agonist of adenosine A2breceptor, with an EC50 of 3-10 nM for human A2breceptors and >10 μM for A1 and A2areceptors. It binds to adenosine A2breceptor in mice, rabbits, and dogs with Ki of 750 nM, 340 nM, and 330 nM, respectively. It also enhances the antitumor activity of chimeric antigen receptor-modified T cells.